No Significant Risk Level (nsrl) for the Proposition 65 Carcinogen Polygeenan

The cancer potency of polygeenan was estimated from dose-response data of colorectal tumors among male and female rats exposed orally (Wakabayashi et al., 1978). The cancer potency estimate corresponds to the upper 95 percent confidence bound on the linear term of the multistage model fit to cancer dose-response data in animals. The potency derivation takes into account body size differences between humans and experimental animals. The Proposition 65 “no significant risk level” (NSRL) is defined in regulation as the daily intake level posing a 10 lifetime risk of cancer. The cancer potency estimate and the corresponding NSRL are given in Table 1.